Monday, 14 October 2013

Individual Topical Review Paper: Performance Enhancing Drugs

1.Executive Summary

Throughout history, men has been trying to perform and outdo their predecessors. We celebrate when records are broken because we believe that as humans that record indicates evolution of our species.
This paper will seek to understand and evaluate how performance enhancing drugs has changed and evolved over time and how athletes are breaking records faster than they can set them. Moreover, it will provide a current and future perspective and of PEDs in the field of sports. In my opinion, Performance Enhancing Drugs (PEDs) can be defined as substances or methods used by athletes to improve their performance in their field of sport. I will attempt to address the anti-doping crusade and how it is doomed to fail and we will see an advent of sub-categories for our athletes; Natural / Enhanced / Superhumans.
The author wishes to express that his topic is extremely sensitive to athletes and evidences gathered are mostly anecdotes which might not seem credible. He does attempt to provide concrete cases of athletes that were caught doping. However, these cases are rare and as such may seem to have provided a myopic view.

2. Introduction

Ever since the dawn of mankind, men has been trying to establish who the most alpha male is, primitive tests would include who’s the best hunter or fighter. However, after becoming civilized, we could no longer use these tests and instead, we compete through sports. Humans attempt to establish their legacy and superiority through setting world records and spectators celebrate as new world records indicates that we are advancing as a specie.
However, evolution doesn’t occur within centuries, much less within decades. Athletes realized that they are restricted by their natural abilities and found it tough to break barriers. Moreover, spectators have high expectations of athletes, they expect to witness records being broken every Olympic Games which is held once every 4 years. The stress of performing has turned our athletes to engage in PEDs to unlock their potential as well as allowing them to train more frequently to push past their limits.
PEDs has been used since the time of the original Olympic Games, from 779 BC to 393 BC.[1] Early forms of PEDs were naturally occurring substances such as hydromel (an alcoholic beverage made from honey) and coffee. These early PEDs allowed users to have an edge over their competitors and outperform them. Therefore we know that PEDs has been a part of human history, many has misconceptions that PEDs were spun-offs of improving technology!
This paper will examine the historical use of PEDs, why were some of them invented and for what purposes. It will examine the current situation thereafter and what are some social implications that has risen with usage of PEDs and how the current anti-doping policy is doomed to fail. This paper will also bring to you a future perspective of competition whereby we begin to embrace such advances and also what implications will it bring with it.
The limitations of this paper will include lack of reliable resources to show the pervasive use of performance enhancing drugs as these are considered to be secrets of athletes. In addition, the author could have prior biasness against performance enhancing drugs as he is a competitive natural bodybuilder and powerlifter where drugs are common and considered as norms. However, the author has tried his best to provide an objective overview of the topic and his exposure to athletes whom used performance enhancing drugs allowed him to provide clearer perspectives.

3. Historical Perspective

The Modern Olympic Games was founded in 1894 by Baron Pierre de Coubertin after being inspired by the Ancient Olympic Games which were held in Olympia, Greece from 8th century BC to 4th century AD.[2] In 1904, Olympic marathon runner, Thomas Hicks, was using a mixture of brandy and strychnine. It was common practice for coaches to have their own unique mixture for their athletes to allow them to have an edge over their competition. In 1928, The International Association of Athletics Federation (IAAF) decided to prohibit doping by athletes as it was deemed to be harmful and could be fatal at times.
In 1950s, athletes were using amphetamines to ward off fatigue and increase their alertness. Amphetamines were created to treat attention deficit hyperactive disorder (ADHD) but was subsequently abused by athletes in order to better their competitors.
The explosion of PEDs came in 1958, when Dr. John Bosley Zieglar created an androgenic anabolic steroid called dianabol after witnessing the success of Russian weightlifting team in the 1954 Olympic Games. This was made worst when the Food and Drug Adminstration(FDA) approved the sale of steroids in 1958 after witnessing promising trials in other countries. Dianabol also known as Methandrostenolone reacts strongly with the androgen receptors which includes increases in protein synthesis, and muscle strength over a short span of time. This allowed athletes to dramatically increase their muscle mass which could be observed in the bodybuilding scene where drugs are pervasive. Comparing 2 bodybuilders, Steve Reeves in 1950 and Arnold Schwarnenegger in 1970s.Arnold has admitted to steroid usage during his years as a champion bodybuilder.[3]
Arnold Schwarnenegger in 1970s.                Steve Reeves in 1950s.
The pervasiveness of PEDs could be observed in the 100m race held on 24th September 1988, at the Seoul Olympics. Labeled as the ‘dirtiest race in history’[4], 6 out of the 8 100m contestants were linked to drug usage, the utter disregard for ethics, fair play and honesty, the trampling of the Olympic spirit. In particular, Ben Johnson, who was once regarded as the best sprinter in the world, has been caught doping not once, but thrice! He was tested positive for stanozolol at the 1988 Olympics. In 1993, he tested positive for testosterone. Finally, he tested positive for a third time – for a diuretic – in 1999 (Moore, 2012). From this example, we could see that elite athletes are willing to take that calculated risk in order to win that gold medal.
In 1990, United State Congress passes the first anabolic control act, placing anabolic steroids under Schedule III [5]of Controlled Substance Act(CSA). The objective was to remove the use of anabolic steroids in competitive sport and also the ability for an individual to acquire them for personal reasons such as aesthetics purposes. While the intrinsic reason for banning of steroids is legitimate, the author feels that there was a lack of enforcement of this act, and we can observe this through the current situation of doping.
In 2002, Dr.Don Catlin identifies for the first time in an athlete’s urine sample norbolethone, [6]the first reported designer steroid.[7] Subsequently, in the years 2003 and 2004, more designer steroids were found. They were created with every intention to cheat the doping test, athletes who used these forms of designer steroids can be considered as deliberate cheaters. An example of an athlete whom used designer steroids would be Tammy Thomas, a former American Track and Field cyclist, who won a silver medal at the 2001 UCI Track Cycling World Championships in the individual sprint event. She got convicted of anabolic abuse and was banned for life from cycling. However, instead of feeling remorseful of her actions, she actually accused the jury of taking away her career away from her. What we can gather from this instance is that athletes feel that even with doping, they are playing at a fair level because it can be assumed that all elite athletes are doping one way or another. As such, Thomas after being convicted, felt that she was unfairly judged and stormed away from the courtroom.
PEDs are not just used to enhance human abilities. In 2009, winner of Kentucky Derby was tested positive for steroids for the first time. Big Brown’s trainer Rick Dutrow administers stanozolol to his horses every 15th of the month. With regards to injecting horses with steroids, it is not considered illegal. Animals are seen as mere objects for humans to use in order to win and injecting them with PEDs is considered a norm. However, Australian horse racing is banning anabolic steroid use for their horses in a pledge for zero tolerance on PEDs.
After researching on these cases, the author is convinced that PEDs will continue to plague our sport industry even with increasing stringent doping procedures. Therefore the author will examine the doping procedures later in this paper and determine if it is adequate, and if not, provide certain solutions to this conundrum.

4. Current Perspective:

In this column, the author will examine firstly, how athletes are able to abuse PEDs without getting caught. Secondly, the transition from using anabolic steroids to Human Growth Hormones (HGH). Lastly, he will examine the doping procedures and determine if it is adequate in curbing PEDs.

4.1 How Athletes are able to abuse PEDs without getting caught
In particular, we will examine the case of Lance Armstrong, winner of 7 Tour De France, got caught for doping. How is it possible, for someone to have passed all the doping tests while competing over the span of a decade only to get busted later on? Lance Armstrong decided to come clean only after being accused of doping by his former teammate, Floyd Landis. Mr Landis’s accusations were sent to a small group of cyclists but were made public by the Wall Street Journal. Mr Landis accused Armstrong of using a performance enhancing cocktail that consisted of Erythropoiethin(EPO), Human Growth Hormones, testosterone and blood transfusion. These drugs were used and monitored closely by his team’s doctor whom had expertise knowledge in these drugs and were able to manipulate Armstrong’s hormonal level to cheat doping tests. For example, EPO boosts red blood cell counts, however, before the year 2000, there were no doping tests that could distinguish the synthetic version of the hormone from its natural counterpart. As such, as long as athletes were able to keep their hematocrit[8] in an acceptable range (below 50%), they could use EPO to boost their red blood cell counts. Another drug that was abused would be testosterone, it is used to improve muscle mass, muscle recovery and promote endurance. However, testosterone levels vary from person to person, and having an accurate baseline level would be near impossible. An article that was posted by Yahoo News mentioned that athletes in the 2012 Olympics were allowed to have four times the normal levels of testosterone before they tipped a drug test. Therefore, it is possible for athletes to abuse testosterone in small dosages to give themselves an edge, but not a positive test. However, athletes are subjected to surprise doping tests, and similarly, they have a counter measure to these tests. Team doctors would dilute their blood with saline solution to quickly drive down hematocrit level which could allow them to pass both the EPO and blood transfusion tests.
Through this case study, the author wishes to highlight the limitations of anti-doping tests and how athletes are able to find loopholes and take advantage of it.
4.2 Advances of PEDs to Human Growth Hormones
The Human Growth Hormone is a naturally occurring peptide hormone produced by the anterior pituitary gland. It was an arduous and complicated task trying to acquire GH back in the 1940s, it had to be isolated from the human pituitary gland and it was extremely limited.[9] Usage of GH was strictly limited to research or therapeutic purposes. However, this was changed in 1985 when they innovated the biosynthetic human growth hormones also known as somatropin. They were able to synthetically create a protein that is nearly identical to the main form of the naturally occurring human growth hormone.
However, this drug was also abused by athletes who are trying to pursue their dream. The most famous case of GH abuse came to light in 1988 following Ben Johnson’s steroid scandal, both he and his coach admitted under oath that Johnson was taking a mix of GH and anabolic steroids. Another example would be Canadian sprinter Angella Issanjenko whom also admitted to using HGH along with other drugs. It is believed that athletes switched from anabolic steroids to HGH as it is considered highly undetectable and doping tests include a blood test which is extremely costly. [10]

4.3 Anti-doping bound to fail

Fig 1. Olympic Drug Testing Chart
Upon researching into the anti-doping system in sports, the author has concluded that it is inadequate and bound to fail. The actual rate of success of anti-doping testing in some cases has been said to be less than 10% and on average less than 50%. From Figure 1, the number of athletes that got tested positive for steroids in the 2004 Athens game is 0.008%! This shows that the probability of getting tested positive is extremely small. There are several components to which an athlete has to commit in order to test positive, they are window of detection, test sensitivity, how often doping occurs and test predictability. The probability in which anti-doping agencies can successfully determine which athlete is doping is extremely small. Furthermore, the cost of urine testing an athlete per year is approximately 21,190.86 euros. As such, in Germany where there is approximately 4000 athletes, the total cost of testing every one of them would exceed 84 million euros! However, the total annual revenue for the Nationale Anti-Doping Agentur Germany in 2011 was approximately around 4.5 million euros, which would result in close to 80 million euros shortfall! Therefore, with the lack of appropriate funding, they could only handpick random athletes to conduct tests on them. This is inadequate! In order to have a fair playing level, every athlete has to be tested and ensure they are not on any PEDs. With that said, even with testing, the probability of ensuring that every athlete is natural is extremely slim as athletes would have used cleansing or masking drugs to cheat the anti-doping tests.

5. Future perspectives

Looking into the future, PEDs will only become more sophisticated and becoming increasingly difficult to detect. With gene therapy already in place, there is no stopping athletes to abuse this aspect of technology. Instead of injecting synthetic Erythropoietin (EPO)[11] into their bodies, they could opt to upgrade the gene responsible for producing more red blood cells. Investing more money into anti-doping test is akin to throwing money at an abyss, it is eventually a zero-sum game. Even with anti-doping tests in place and banning of such substances, athletes will still take the calculated risk and engage in PEDs in order to have an advantage over their competition. Therefore the author would suggest creating sub-categories for athletes to compete in; natural, enhanced or prosthetic/genetically enhanced athletes.

5.1 Sub category for competition

Before the introduction of sub categories, we must first acknowledge that PED usage is pervasive and will not stop. Instead of penalizing the usage of PEDs, we supervise athletes who have decided to go down this road. These categories should be considered mutually exclusive with no base of comparisons even if they are competing in the same sport or event. There should not be any discrimination of athletes in any categories as it is considered as their choice and they are fully aware of the risks that they are undertaking
For natural athletes, this category still require some forms of anti-doping measures, however it should be reserved for the top athletes who has a higher probability of doping. The results of this category could be a basis for human evolution over time and show different eras of athletes. This category of natural competition can already be observed in the bodybuilding arena. Professional natural bodybuilding organizations such as the Professional Natural Bodybuilding Association (PNBA), International Fitness and Physique Association (IFPA) or World Natural Bodybuilding Federation (WNBF) provides an avenue for natural bodybuilders who do not use performance-enhancing drugs to compete in. They do not explicitly state that other bodybuilding shows are plagued with PEDs, but rather, they acknowledge the fact that PEDs are rampant and provide an alternative avenue for natural athletes to compete in.
How about the Singapore context? The recent scandal of Singapore Bodybuilding Federation (SBBF) being delisted by Singapore Sports Council after failing to explain a number of controversies, including doping at the Singapore National Bodybuilding and Physique Sports Championships. In addition, 7 bodybuilding athletes got tested positive for prohibited substances and received a two-year ban. The author feels that such a ban would not discourage further usage of PEDs as it is common knowledge that bodybuilders use such anabolics to prepare themselves for competition. These banned athletes would just treat this 2-year ban as a good time to indulge in even more anabolic steroids and return even better than before. As such, the author feels that instead of imposing just a 2-year ban, Singapore should have imposed a heavier penalty, or a life-time ban. Singapore could be the epitome for natural competition, we could be the first to host natural competitions once our national stadium is built, and if any athletes found to be using PEDs, they would be imposed with a lifetime ban and never to return to Singapore again. Such a ban could really create the new arena for natural athletes to aspire to compete in.
For enhanced athletes, this is a category whereby the athletes understand the risks involved with the consumption of such PEDs and still wishes to do so. It can be assumed that all athletes participating in the enhanced categories are under the influence of PEDs and their results may not be a good gauge of athletic performance throughout the years as PEDs continue to advance and have even greater effects on human performance. Most of the anti-doping funds could be channeled into this category, it could be used to provide athletes with proper doctor supervision of their PEDs. This category of athletes will allow doctors to experiment with different drug usage and witness for themselves the effects of their drugs. Spectators who constantly demand more out of an athlete could be enticed to sponsor these athletes as they push the boundaries of human capabilities and excite us with even more breath taking records.
Lastly, the most controversial category for the prosthetic/genetically enhanced athletes. This category of athletes would have undergone either gene manipulation or have enhanced prosthetics attached to them. Gene manipulation will be in the near future, genes that control the production of red blood cells could be upgraded and essentially these athletes could have superhuman regenerative abilities, sounds pretty far-fetched? Just keep in mind that gene therapy is already in place, they could easily use it for gene manipulation. How about enhanced prosthetics? Robotic arms or legs that outperform human limbs? The well-known blade runner Oscar Pistorius who’s an amputee that competes in the normal Olympics has caused a huge dispute over his prosthetics. He runs with J-shaped carbon fibre prosthetics called the “Flex-Foot Cheetah” developed by biomedical engineer Van Philips and manufactured by Ossur. Pistorius used significantly less oxygen than able-bodied sprinters, 25% less during sprinting and 17% less during jogging[12]. How about the controversial swimsuit, LZR, which allowed our athletes to break numerous world records at the 2008 Beijing Olympics? The swimsuit was able to compress a swimmer’s body into a streamlined tube and trapped air, adding buoyancy and reducing drag. With this category in place, we will no longer be impeding the advances of technology and engineers will be free to invent such attachments. However, in order to ensure fair play amongst athletes in this category, all of the athlete should be using the exact same attachment, this would ensure that there is no discrepancies in their performances. This category will also expedite the innovation process where engineers are able to bring their products to the market.
5.2 Ethics of PEDs usage
Some argue that athletes using PEDs are considered as cheaters and ethically wrong because they have an unfair advantage over their competitors. However, the underlying assumption is that other competitors are not under the influence of PEDs, this is usually not the case. Just look into the controversial baseball PED scandal in America, where Major League Baseball (MLB) stars Alex Rodriguez, Gio Gonzalez and Barry Bonds are tied to the steroid scandal. The fact is that any sport that involves money and fame usually has PEDs ingrained in them. Spectators should no longer harbor that wishful thinking that their athletes are clean because they are not. Therefore the accusation of an athlete using PEDs as a cheater has false premises and is not sound. We could solve this ethical issue of PED usage with the aforementioned sub category competitions. Spectators should acknowledge that athletes are willing to take that calculated risk in order to win and gain fame or success in their sport. Moreover, spectators should be blamed for the advent of PEDs in sports as well, because we demand for faster 100m runs, more homeruns and better physiques. We believe that as humans we are capable of so much more and we put pressure on our athletes to continue entertaining us with better performances.

6. Conclusion

Encapsulating the aforementioned, the author has examine the development of Performance Enhancing Drugs, from the invention back in 1958 to the evolution into Human Growth Hormones in 1985. Currently, we are labeled as the steroid era, whereby there is no sport that has not been tainted by the use of PEDs. That is due to the competitive nature of humans wanting to outperform each other, even at the expense of using PEDs. Even in Singapore, the advent of PEDs can be seen by our local bodybuilders returning positive for their doping tests. Furthermore, the author has looked into the anti-doping policy and found that it is inadequate. He has provided a viable option to create sub categories for athletes to compete in, this would not only solve ethical issues concerning PEDs but also a reallocation of resources to ensure the health of our athletes.
Through this paper, the author wishes to highlight awareness regarding the prevalence of PEDs and the ignorance that the general public has about their athletes. He feels that resisting PEDs is a zero-sum game which would result in the loss of millions of dollars and still provide no concrete solution to this conundrum. Therefore, he urges the general public to become more receptive of PEDs, this will allow our athletes to come clean with their PED usage and engage in doctor supervision.

Reference

   1.       (2012, July). Two-year ban for seven bodybuilding athletes who tested positive for prohibited substances. Retrieved from: http://www.ssc.gov.sg/publish/Corporate/en/news/media_releases/2012/TWO_YEAR_BAN_FOR_SEVEN_BODYBUILDING_ATHLETES_WHO_TESTED_POSTIVE_FOR_PROHIBITED_SUBSTANCES.html Date retrieved: 28th September 2013
   2.      (2012, Oct). How did Lance Armstrong Avoid a Positive Doping Test? Retrieved from: http://news.yahoo.com/did-lance-armstrong-avoid-positive-doping-test-182038095.html . Date retrieved: 14th October 2013 
   3.      Ayyar, V. (2011). History of growth hormone therapy. Indian Journal of Endocrinology and Metabolism. Retrieved from: http://ehis.ebscohost.com.libproxy.smu.edu.sg/eds/detail?vid=3&sid=e5290bc1-a66f-4401-b2cd-79368a233f41@sessionmgr114&hid=102&bdata=JnNpdGU9ZWRzLWxpdmUmc2NvcGU9c2l0ZQ==#db=a9h&AN=66844925. Date retrieved: 28th September 2013 
   4.      Figure 1: Olympic Drug Testing. Retrieved from: http://www.cbsnews.com/htdocs/sports/doping/framesource_chart.html
   5.      Guha, N. & Sonksen, P. & Holt, R. (2010, Dec). Growth hormone abuse: a threat to elite sport. Biologist. Retrieved from: http://ehis.ebscohost.com/eds/detail?sid=36579f7b-b9cf-44be-9366-04f2bf5b19d3%40sessionmgr115&vid=1&hid=102&bdata=JnNpdGU9ZWRzLWxpdmUmc2NvcGU9c2l0ZQ%3d%3d##db=a9h&AN=59207775 . Date retrieved: 28th September 2013   
   6.      Hermann, A. & Henneberg, M. (2013, July) Anti-doping systems in sports are doomed to fail: a probability and cost analysis. Retrieved from: http://www.adelaide.edu.au/news/binary9861/Doping.pdf . Date retrieved 28th September 2013
   7.      Holt, R. (2011, May). Detecting growth hormone abuse in athlete. Analytical & Bioanalytical Chemistry. Retrieved from: http://ehis.ebscohost.com/eds/detail?vid=2&sid=992e6ccb-84c2-4eac-b6bd-17b2217cf639%40sessionmgr111&hid=102&bdata=JnNpdGU9ZWRzLWxpdmUmc2NvcGU9c2l0ZQ%3d%3d#db=a9h&AN=62519960 . Date retrieved: 28th September 2013
   8.      Holt, R. , Mulligan, I. , Sonksen, P. (2008, Jun). Growth hormone, IGF-1 and insulin and their abuse in sport. British Journal of Pharmacology. Retrieved from: http://ehis.ebscohost.com.libproxy.smu.edu.sg/eds/detail?vid=5&sid=e5290bc1-a66f-4401-b2cd-79368a233f41%40sessionmgr114&hid=109&bdata=JnNpdGU9ZWRzLWxpdmUmc2NvcGU9c2l0ZQ%3d%3d . Date retrieved: 28th September 2013
   9.      Madrigal, A. (2012, Aug). By the Next Olympics, Athletes May Be Getting Routine Gene Doping Tests. Retrieved from: http://www.theatlantic.com/technology/archive/2012/08/by-the-next-olympics-athletes-may-be-getting-routine-gene-doping-tests/260700/ . Date retrieved: 28th September 2013
   10.    Moore, R. (2012, Aug). The dirtiest race in history: It’s the glamour moment of the Games, but will we ever forget the stain of Seoul. Retrieved from: http://www.dailymail.co.uk/sport/olympics/article-2182781/London-Olympics-2012-Recalling-100m-mens-final-Seoul--dirtiest-race-history.html . Date retrieved: 28th September 2013
   11.      Tucker,S. Dugas, J. (2011, Aug). From the go-kart racer to the F1 driver: The scientific interpretation of the Pistorius research. Retrieved from: http://www.sportsscientists.com/2011/08/scientific-interpretation-of-oscar.html . Date retrieved: 28th September 2013
   12.     William, L. (2008, Apr). Thomas found guilty of lying in BALCO probe. Retrieved from: http://www.sfgate.com/bayarea/article/Thomas-found-guilty-of-lying-in-BALCO-probe-3219287.php . Date retrieved: 28th September 2013




[2] Start of Modern Olympic Games, URL: http://en.wikipedia.org/wiki/Olympic_Games
[3] Arnold: No Regrets about Steroids, URL: http://www.cbsnews.com/2100-250_162-676684.html
[4] The dirtiest race in history: It’s the glamour moment of the Games, but will we ever forget the stain of Seoul. Retrieved from: http://www.dailymail.co.uk/sport/olympics/article-2182781/London-Olympics-2012-Recalling-100m-mens-final-Seoul--dirtiest-race-history.html.
[5] Schedule III controlled substances: Drugs that possess a viable medical purpose but do carry with them the risk of dependency and physical damage.
[6] Norboletone is an anabolic steroid that is reputed to have been the active ingredient in the original formulation of ‘undetectable’ steroid formulation.
[7] Key Anti-Doping and Doping developments in Sport. Retrieved from: http://www.antidopingresearch.org/Lab_Library_AD_Timeline.html
          [8] Hematocrit: The ratio of red blood cells to the total volume of blood

[11] Erythropoietin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production.
[12] The scientific interpretation of the Pistorius Research. Retrieved from: http://www.sportsscientists.com/2011/08/scientific-interpretation-of-oscar.html

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